30-Year Longitudinal Study of Hematological Parameters of HIV-1 Negative Men Participating in Los Angeles Multicenter AIDS Cohort Study (MACS)

Educational objectives:

• To recognize the common biological factors that affect the laboratory test results that are important for clinical decision making by the physician.
• Understand the importance of intra-individual and inter-individual biological variation in a clinical setting.
• The role of index of individuality (II) and evaluating the usefulness of population-based reference intervals (RI).
• Evaluating direction and magnitude of changes in each blood marker from baseline through the 30-year follow-up period.