Concentrations of Serum Free Light Chains in Kappa and Lambda Lesions in Light-Chain Myelomas

Educational Objectives:

• To recognize the biological variations in monoclonal gammopathic disorders with respect to the structure of involved immunoglobulin.
• To understand the basis for the serum free light chain assay
• To understand the limitations of serum free light chain assay.
• To understand the role of oligoclonal response and its effect on interpretation of serum free light chain assay.
• To recognize the current role of serum free light chain assay as part of the criteria for myeloma defining conditions.