Immunohistochemical Nuclear Expression of ß-Catenin as a Surrogate of CTNNB1 Exon 3 Mutation in Endometrial Cancer

Online journal article in Molecular Pathology that offers 1.0 continuing education (CME/SAM) credit that can be used to fulfill CC Part II requirements.

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Intended Audience: Pathologists, Residents, Clinical Scientists, Pathologist Assistants

Upon completion of this activity, you will be able to:

list the four TCGA molecular groups of endometrial cancer with their prognostic significance, molecular signatures, and immunohistochemical surrogates.

Intended Audience: Pathologists, Residents, Clinical Scientists, Pathologist Assistants

Upon completion of this activity, you will be able to:

list the four TCGA molecular groups of endometrial cancer with their prognostic significance, molecular signatures, and immunohistochemical surrogates.
describe the molecular group of endometrial cancer in which CTNNB1 exon 3 mutation has a prognostic value, and how it may affect the prognosis.
describe the possible application of immunohistochemistry for ß-catenin in the risk stratification of endometrial cancer, how it could be integrated in the Proactive Molecular Risk Classifier for Endometrial Cancer (ProMisE), and how it could be interpreted.

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Immunohistochemical Nuclear Expression of ß-Catenin as a Surrogate of CTNNB1 Exon 3 Mutation in Endometrial Cancer

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