MEGAN SWEENEY, MLS(ASCP) MB
Circulogene Theranostics
Pensacola, Florida
Primary Audience: Phlebotomists, Laboratory Technologists, Laboratory Directors
Secondary Audience: Pathologists, Clinical Scientists (Includes all sub-specialty areas), Students, Pathologist Assistants, Residents, and Students
Upon completion of this activity, you will be able to:
· explain the inheritance pattern of Lynch syndrome and the likelihood of passing from one generation to the next;
· differentiate the proteins involved in the mismatch repair system based on their roles in the process;
· illustrate the expected results of a microsatellite stable (MSI-S) and a MSI-high (MSI-H) capillary electrophoresis run;
· discuss the correlation of MSI/immunohistochemistry (IHC) results with those genes for Lynch syndrome detected via next-generation sequencing; and
· describe the clinical utility of IHC and MSI test results even if the patient does not have Lynch syndrome.