LabQ Clinical Exercise 7: Hematology: Atypical Lymphocytosis With Villous Lymphocytes in a Patient With Splenic Marginal Zone Lymphoma

Xenia Parisi, MD 

Jie Xu, MD, PhD 

The University of Texas MD Anderson Cancer Center 

Houston, Texas 

Primary Audience:

Phlebotomists, Laboratory Technologists, Laboratory Directors

Secondary Audience:

Pathologists, Clinical Scientists (Includes all sub-specialty areas), Students, Pathologist Assistants, Residents, and Students

Upon completion of this activity, you will be able to: 

·        describe the clinical presentation of a patient with splenic marginal zone lymphoma (SMZL); 

·        describe the spectrum of morphologic features of SMZL cells seen in peripheral blood and bone marrow smears; 

·        discuss the immunophenotype of SMZL; 

·        discuss the differential diagnosis of SMZL; and 

·        discuss the prognosis of patients with SMZL.