Flow cytometry evaluation of acute myeloid leukemia minimal residual disease based on an understanding of the normal maturation patterns in the blast compartments

Online journal article in Hematopathology that offers 1.0 continuing education (CME) credit that can be used to fulfill CC Part II requirements.

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Intended Audience: Pathologists, Residents, Clinical Scientists, Pathologist Assistants

Upon completion of this activity, you will be able to:

Describe and compare the conceptual frameworks of the Leukemia-Associated Immunophenotype (LAIP) approach and the “difference from normal” (DFN) approach...

Intended Audience: Pathologists, Residents, Clinical Scientists, Pathologist Assistants

Upon completion of this activity, you will be able to:

Describe and compare the conceptual frameworks of the Leukemia-Associated Immunophenotype (LAIP) approach and the “difference from normal” (DFN) approach in the flow cytometric work-up of minimal/measurable disease (MRD) in patients with acute myeloid leukemia (AML).

List the expected cell surface markers that characterize cells along the maturational pattern in normal hematopoietic development within the myeloid lineage.

Summarize the patterns of cell surface markers that can assist detection of minimal/measurable disease (MRD) in patients with acute myeloid leukemia (AML).

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