Release Date: Mar 2017
CC: PC, MK, PBL
Christine P. Collier, PhD, FCACB
Clinical Biochemist, Kingston General Hospital, Kingston, ON, Canada; Professor, Queen's University, Kingston, ON, Canada
Laboratory testing often plays a central role in the diagnosis and monitoring of disease. Results are interpreted by comparison with population reference intervals or medical decision limits, as well as with previous patient results. The laboratory is responsible for understanding and optimizing the pre-analytical, analytical and post-analytical factors that contribute to result interpretation and ultimately optimized patient care.
The establishment and validation of reference intervals can be challenging and costly. Currently, there is significant variation in reference intervals, even across laboratories using the same methods and instruments. For quite a few analytes there is minimal analytical and biological evidence to support these differences. Over the last decade, harmonization initiatives have progressed at the regional, national and international levels. When possible to achieve, harmonized reference intervals should help to standardize patient care.
After attending this session, participants will be able to:
· Discuss the general elements associated with harmonization of a clinical laboratory test, with emphasis on the pros and cons of harmonizing reference intervals.
· Compare the approach and outcomes of different initiatives undertaken to date to harmonize reference intervals.
· Critically consider the value and the steps necessary for incorporating harmonized reference intervals for selected tests in their own laboratories.
Who should attend? Practicing Pathologists, Residents, Doctoral Scientists, Laboratory Managers, Bench Supervisors, Bench Technologists & Technicians, Students