Release Date: Mar 2017
CC: PC, MK, PBL
Dorothy M. (Adcock) Funk, MD
Medical Director, Colorado Coagulation, Englewood, CO
Most clinical laboratories that offer factor activity assays, perform one-stage assays only and do not offer chromogenic factor VIII and IX activity assays. Based on the difference in methodology, chromogenic factor activity assays can be useful and in certain circumstances, provide more accurate results. This is particularly important to those laboratories that follow patients with hemophilia A or B. This program will review the methodologies of the one-stage and chromogenic factor VIII and IX activity assays and describe those clinical situations where the chromogenic assay should be used. Limitations of the chromogenic factor VIII and IX activity assays will also be presented.
After attending this session, participants will be able to:
· Explain the basic differences between a one-stage factor activity assay and a chromogenic factor activity assay.
· Describe the reason for including the chromogenic factor VIII activity assay in the evaluation of non-severe hemophilia A.
· List the clinical circumstances in which a factor VIII or factor IX chromogenic activity assay may be advantageous over a one stage factor VIII or factor IX activity assay.
· List the limitations of the chromogenic factor VIII and IX activity assays.
Who should attend? Practicing Pathologists, Residents, Doctoral Scientists, Laboratory Managers, Bench Supervisors, Bench Technologists & Technicians, Hematologist, Oncologists, Students