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Thrombotic Thrombocytopenic Purpura

Thrombotic Thrombocytopenic Purpura

Release Date: Apr 2017


George M. Rodgers, MD, PhD
Professor of Medicine, University of Utah Medical Center, Salt Lake City, UT



Thrombotic thrombocytopenic purpura (TTP) is an uncommon thrombotic microangiopathic (TMA) disorder, frequently confused with other TMAs- typical and atypical hemolytic-uremic syndromes. TTP results from either inherited or acquired deficiency of ADAMTS13. Deficiency of ADAMTS13 results in failure to process ultra-high-molecular-weight multimers of von Willebrand factor, leading to widespread platelet thrombosis. This presentation will summarize TTP pathogenesis, laboratory features, distinguish TTP from the TMAs, suggest a laboratory pathway of diagnosis, and briefly describe current and future treatment options.

After attending this session, participants will be able to:

·        Understand the pathogenesis of Thrombotic Thrombocytopenic Purpura (TTP).

·        Distinguish TTP from other thrombotic microangiopathies (TMAs).

·        Understand appropriate laboratory testing for diagnosing TMAs.

Who should attend?  Practicing Pathologists, Residents, Doctoral Scientists, Bench Technologists & Technicians

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Item Details:
Thrombotic Thrombocytopenic Purpura
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