Release Date: Oct 2017
CC: PC, MK, PBL
Qing H. Meng, PhD, MD, DABCC, FCACB
Laboratory Director, University of Texas MD Anderson Cancer Center, Houston, TX; Professor, University of Texas, Houston, TX
Hypercortisolism and hypocortisolism are disorders characterized by glucocorticoid excess and insufficiency, respectively. Clinical decision making for patients with suspect hypercortisolism (Cushing's syndrome) or hypocortisolism (Addison's disease) involves a complex diagnostic assessment and laboratory investigation. Prompt diagnosis is important as each of the disorders represents challenging endocrine pathologies which could pose significant impact on quality of life, severe clinical complications, and even mortality. Advances in understanding of the etiologies and pathophysiologies of these disorders would help to illustrate their clinical features and provide the means for early and accurate diagnosis so that proper therapy can be initiated. Improved diagnostic tests and procedures have increased the ability to recognize even subclinical disorders. Despite these advances, the occurrence of unusual or nonspecific clinical presentations and laboratory shortcomings may delay the diagnosis and patient management. Therefore, efficient screening and diagnostic tests are needed to identify those patients with symptoms potentially related to cortisol excess or insufficiency. This presentation will provide an update on the pathological, biochemical, and clinical features of these diseases. Moreover, the most recent recommended tests and methods as well as the approach for screening, differential diagnosis, and diagnosis of these disorders will be disseminated.
After attending this session, participants will be able to:
· Understand the different etiologies and pathophysiologies of hypercortisolim and hypocortisolism.
· Recognize the clinical features of Cushing's syndrome and Addison's disease.
· Discuss the screening tests for Cushing's syndrome and Addison's disease.
· Implement diagnostic and differential diagnostic approaches for Cushing's syndrome and Addison's disease.
Who should attend? Practicing Pathologists, Residents, Doctoral Scientists, Laboratory Managers, Bench Supervisors, Bench Technologists & Technicians, Students