Case Reports Cytopathology 2018 Exercise 6:Diagnosis of Fibrolamellar Hepatocellular Carcinoma by Fine-Needle Aspiration Cytology: Cytomorphologic Features of a Rare Tumor (CSCY1806)

Linnea Anne Swanson, BA
Medical Student
Department of Laboratory Medicine and Pathology
University of Minnesota System

Sophia Smith, MD
Staff Pathologist
Department of Pathology
Hennepin County Medical Center

Khalid Amin, MD
Assistant Professor
Department of Laboratory Medicine and Pathology
University of Minnesota

Minneapolis, Minnesota

Primary Audience: Pathologists and Clinical Scientists

Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

• identify characteristic cytomorphologic features of fibrolamellar hepatocellular carcinoma on cytology smears;
• formulate an immunohistochemistry panel to differentiate fibrolamellar from conventional hepatocellular carcinoma;
• describe the recently identified fusion gene and its relation to fibrolamellar pathogenesis; and
• correlate key clinical features of fibrolamellar hepatocellular carcinoma with pathologic findings.