Case Reports Hematopathology 2018 Exercise 1: Chronic Myeloid Leukemia Blast-Phase Transformation With Erythroid Differentiation (CSHP1801)

Authors

Yang Shi, MD, PhD
Assistant Professor
Attending Hematopathologist
Department of Pathology
Montefiore Medical Center
Albert Einstein College of Medicine
Bronx, New York

Intended Audience: Pathologists, Residents, Clinical Scientists, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

• identify different phases of chronic myeloid leukemia (CML);
• recognize the different variants of blast transformation in CML;
• formulate a differential diagnosis for blast-phase CML with erythroid differentiation;
• describe the histopathologic features of blast-phase CML with erythroid differentiation; and
• integrate the findings of MLL genetic aberrations in the acute leukemias, especially acute myeloid leukemia, into pathology reports.