Case Reports Hematopathology 2018 Exercise 5: Hemophagocytic Lymphohistiocytosis (CSHP1805)

David T. Yang, MD
Associate Professor

Yanping Wang, MB, PhD, MMS
Resident Physician PGY2

Department of Pathology and Laboratory Medicine
University of Wisconsin School of Medicine and Public Health
Madison, Wisconsin

Primary Audience: Pathologists and Clinical Scientists

Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

• describe the clinical presentation of hemophagocytic lymphohistiocytosis (HLH);
• integrate the patient’s clinical history with pathologic findings to establish a diagnosis of HLH;
• recognize morphologic features, immunohistochemical staining, and genetic phenotypes of HLH;
• apply the proper diagnostic criteria and terminology to HLH; and
• differentiate HLH from other similar disorders.