Case Reports Renal Pathology 2018 Exercise 1: Fabry Disease (CSRP1801)

Author

Leal Herlitz, MD
Director, Medical Kidney Pathology
Department of Anatomic Pathology
Cleveland Clinic
Cleveland, Ohio

Intended Audience: Pathologists, Residents, Clinical Scientists, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

• integrate the electron microscopic features of Fabry disease with the comparatively nonspecific changes seen by light microscopy;
• discuss the spectrum of clinical findings of Fabry disease, including renal and extrarenal manifestations;
• apply an understanding of the pathogenesis of Fabry disease to recommend appropriate enzymatic and genetic testing to confirm the diagnosis;
• generate a differential diagnosis for the finding of “zebra bodies” in the kidney; and
• discuss medications that can cause iatrogenic phospholipidosis.