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Using the Indirect Hoffmann Method to Estimate Reference Intervals in the Clinical Laboratory

Using the Indirect Hoffmann Method to Estimate Reference Intervals in the Clinical Laboratory

Release Date: Sep 2018

 

CC: PC, MK, PBL, PR, SBP

 

Alex Katayev, MD, DLM(ASCP)

AVP, Director of Clinical Science Assessment, Laboratory Corporation of America Holdings, Burlington, NC 

 

 

 

Description:

 

Providing statistically accurate and methodology-specific population-based reference intervals (RI) for the interpretation of laboratory test results remains a backbone of the clinical laboratory industry. However, RI studies are one of the most difficult to perform due to limiting factors and lack of clear definitions. In recent years, the International Federation of Clinical Chemistry (IFCC) and other professional organizations have provided clarification for performing RI studies. In this course, the indirect Hoffman method of RI calculation will be described. This method uses data mining of the test results already available in the laboratory database and compares different methods of reference interval calculations in the real-life clinical laboratory setting. The proper way to interpret reference interval limits in clinical settings and the differences between reference intervals and clinical decision points will also be discussed.

 

 

After attending this session, participants will be able to:

  • Recognize the advantages and limitations of direct and indirect methods for clinical laboratory reference interval estimation.
  • Identify the necessary steps in performing a statistically reliable estimation of reference intervals.
  • Understand how to perform accurate reference interval calculations using the indirect Hoffmann method.
  • Recognize the difference between a reference interval and a clinical decision point.
  • Apply the proper use and interpretation of reference interval limits in clinical practice.

 

Who should attend?  Practicing Pathologists, Residents, Doctoral Scientists, Pathologists’ Assistants, Laboratory Managers, Bench Supervisors, Bench Technologists and Technicians, Cytotechnologists, Histotechnologists, Students

  • List Price: $45.00
  • Member Price: $35.00
 
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Using the Indirect Hoffmann Method to Estimate Reference Intervals in the Clinical Laboratory
Back to Using the Indirect Hoffmann Method to Estimate Reference Intervals in the Clinical Laboratory

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