Release Date: Oct 2018
CC: PC, MK, PBL, ICS, SBP
Daniel F. I. Kurtycz, MD, FASCP
Medical Director, Wisconsin State Laboratory of Hygiene, University of Wisconsin School of Medicine and Public Health, Madison, WI; Professor, Department of Pathology, University of Wisconsin School of Medicine and Public Health, Madison, WI
In this webcast, we will address some day-to-day difficulties in gynecologic cytology, investigate morphologic look-alikes, and look at cyto-histology correlations. Basic biologic processes will be discussed that will help participants understand why a sample has a given morphology, rather than just mapping a recognized pattern to a diagnosis. More pointedly, there is often confusion between morphology of the high nuclear-to-cytoplasmic-ratio metaplastic cell and those cells derived from a high-grade intraepithelial lesion. In practice, this confusion is likely to result in increased numbers of overcalls, or at the very least increased numbers of cells irrelevantly dotted for presentation to the senior cytologist. This presentation will show examples and provide support to try and decrease those overcalls. Participants will have a better understanding of the biologic processes and the reasons for morphologic overlaps. The session should also help cytologists in their struggle to separate benign innocuous cells from neoplastic cells worthy of concern during screening and interpretation of gynecologic slide material.
After attending this session, participants will be able to:
- Identify difficulties with a number of morphologic look-alikes and formulate strategies to deal with them.
- Recognize that the imprecision of atypia in Gyn Cytology (ASC-US) is similar to the imprecision in many laboratory tests, and discuss the problem of analytical resolution in clinical laboratory testing.
- Assess examples of benign metaplasia and high grade squamous intraepithelial lesions (HGSIL) and those cases that lie in between in order to decrease the numbers of overcalls and undercalls.
Who should attend? Practicing Pathologists, Residents, Cytotechnologists, Students