LabQ Clinical Exercise 1: Clinical Chemistry: Evaluation of Oxygenation Status in Individuals With Sickle Cell Disease

Primary Audience: Phlebotomists, Laboratory Technologists, Laboratory Directors

Secondary Audience: Pathologists, Clinical Scientists (Includes all sub-specialty areas), Students, Pathologist Assistants, Residents, and Students

Upon completion of this activity, you will be able to:

·         interpret the Clinical and Laboratory Standards Institute’s recommended nomenclature for oxygenation parameters; 

·         evaluate blood oxygen content, hemoglobin states and types, and oxygen-hemoglobin dissociation curves; 

·         differentiate testing principles and performance characteristics of clinical laboratory assays that establish oxygenation parameters;

·         recognize how oxygenation parameters correlate with each other and what their perturbation is in individuals with sickle cell disease (SCD); and

·         distinguish the implications of hypoxemia/hypoxia in SCD pathophysiology and SCD-related morbidity and mortality

·        discuss how the laboratory can support clinical management of oxygenation in individuals with SCD.