LabQ Clinical Exercise 7: Transient Abnormal Myelopoiesis Associated With Down Syndrome

SAM SIROTNIKOV, DO 

Emory University 

Atlanta, Georgia

DENIZ PEKER, MD

Primary Audience: Phlebotomists, Laboratory Technologists, Laboratory Directors

Secondary Audience: Pathologists, Clinical Scientists (Includes all sub-specialty areas), Students, Pathologist Assistants, Residents, and Students

Upon completion of this activity, you will be able to:

·         identify the common presenting laboratory findings in neonates with transient abnormal myelopoiesis associated with Down syndrome (TAM-DS); 

·         recognize the characteristic immunophenotype of blasts in TAM-DS;

·         identify the mutation required for TAM-DS to occur;

·         recognize clinical symptoms predictive of poor survival in TAM-DS; and

·         formulate an appropriate differential diagnosis in a neonate with leukocytosis.