LabQ Clinical Exercise 13: The Importance of the Laboratory Professional in the Diagnosis of Lynch Syndrome

MEGAN SWEENEY, MLS(ASCP) MB

Circulogene Theranostics

Pensacola, Florida

Primary Audience: Phlebotomists, Laboratory Technologists, Laboratory Directors

Secondary Audience: Pathologists, Clinical Scientists (Includes all sub-specialty areas), Students, Pathologist Assistants, Residents, and Students

Upon completion of this activity, you will be able to:

·         explain the inheritance pattern of Lynch syndrome and the likelihood of passing from one generation to the next; 

·         differentiate the proteins involved in the mismatch repair system based on their roles in the process;

·         illustrate the expected results of a microsatellite stable (MSI-S) and a MSI-high (MSI-H) capillary electrophoresis run;

·         discuss the correlation of MSI/immunohistochemistry (IHC) results with those genes for Lynch syndrome detected via next-generation sequencing; and

·         describe the clinical utility of IHC and MSI test results even if the patient does not have Lynch syndrome.