Authors
Robert Bubar, MD
Sarah Wheeler, PhD
Department of Pathology
University of Pittsburgh
Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants, Laboratory Directors and Educators
Upon completion of this activity, you will be able to:
· compare and contrast the 3 main criteria for diagnosis and assessment of acute kidney injury (AKI) in children;
· explain the physiology behind laboratory measurement of serum creatinine as a method of assessing AKI in children;
· explain the physiology behind urine neutrophil gelatinase-associated lipocalin (uNGAL) as a method of assessing AKI in children;
· discuss the benefits and drawbacks of using uNGAL compared with using serum creatinine for assessment of AKI in children;
· identify the ways that uNGAL is being used in the clinical setting and the limitations to implementing it into standard AKI criteria; and
· evaluate serum creatinine and uNGAL findings to diagnose and stratify AKI in pediatric patients based on predicted risk.