Case Reports Hematopathology 2022 Exercise 4: Primary Cold Agglutinin Disease

Authors

Huma Asif, MBBS

Imran N. Siddiqi, MD, PhD, FASCP

Department of Pathology

Keck School of Medicine of the University of Southern California

Los Angeles, California    

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·       define primary cold agglutinin disease (CAD);

·       describe the features of primary CAD-associated lymphoproliferative disorder that formulate a distinct diagnostic entity in the newly revised World Health Organization and International Consensus Classifications;

·       distinguish primary CAD from other clonal lymphoproliferative disorders previously associated with CAD;

·       describe the molecular abnormalities associated with the disease; and

·       explain various treatment modalities for CAD.