Case Reports Forensic Pathology 2023 Exercise 3: Holoprosencephaly

Authors

Natalie E. Finazzo, MD

Department of Anesthesiology

Oakland University William Beaumont School of Medicine

Royal Oak, Michigan

Amanda O. Fisher-Hubbard, MD

Joseph A. Prahlow, MD

Department of Pathology

Western Michigan University Homer Stryker M.D. School of Medicine

Kalamazoo, Michigan

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·         explain, in general terms, the underlying developmental morphologic findings in persons with holoprosencephaly;

·         describe the 3 basic subtypes of holoprosencephaly;

·         detail the most common physical facial anomalies known to be associated with holoprosencephaly; and

·         explain why medicolegal death investigators must have a heightened suspicion for potential abuse/inflicted injuries in decedents with holoprosencephaly.