Case Reports Transfusion Medicine 2024 Exercise 5: Antibodies to High-Frequency Antigens in Pregnancy

Authors

Shelbey Bauman, MD

Ian Harrold, MD

Department of Pathology

Cleveland Clinic

Cleveland, Ohio

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

• discuss the importance of maternal antibodies during pregnancy;
• explain the steps for laboratory evaluation of a high-frequency antibody;
• discuss the noninvasive and invasive methods used to monitor for fetal anemia;
• explain the principle of the monocyte monolayer assay and its utility in assessing antibodies to high-frequency antigens; and
• evaluate blood management strategies for patients with antibodies to high-frequency antigens based on degree of urgency.