Case Reports Transfusion Medicine 2025 Exercise 2: Two Cases of Passenger Lymphocyte Syndrome

Authors

Tricia O’brien, DO, MBA

Edward K. De Leo, MD

Faisal Mukhtar MD, MBBS, FACP, FASCP

Department of Pathology, Immunology, and Laboratory Medicine

University of Florida

Gainesville, Florida

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·       explain pathophysiology of  passenger lymphocyte syndrome (PLS);

·       diagnose PLS from clinical and laboratory findings;

·       explain how PLS can cause ABO discrepancy;

·       discuss the most appropriate blood products for the treatment of  PLS; and

·       recommend various methods to prevent PLS.