Case Reports Transfusion Medicine 2025 Exercise 6: TPE in a Bottle? The Use of Neonatal Fc Receptors and Their Potential Impact on Transfusion Medicine and Apheresis

Authors

Kai Jordan Rogers, MD, PhD

Jensyn Cone Sullivan, MD, CABP

University of Michigan

Ann Arbor, Michigan

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·       explain humoral immunity, and mechanisms of antibody-mediated pathologies;

·       explain neonatal Fc receptor function and therapeutic rationale for its inhibition;

·       describe the current clinical applications for neonatal Fc receptor inhibition;

·       distinguish antibody-mediated diseases that will benefit from neonatal Fc receptor blockade from those that will not; and

evaluate clinical situations that may benefit from neonatal Fc receptor blockade.