Case Reports Transfusion Medicine 2025 Exercise 3: An Overview of Transplant-Associated Thrombotic Microangiopathy and the Changing Role of Apheresis

Authors

Tamao Setaka-Golub, MD

Sarah Kesterson, MD

Penn State Health Milton S Hershey Medical Center

Hershey, Pennsylvania

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·       support the diagnosis of transplant-associated thrombotic microangiopathy (TA-TMA) using appropriate signs/symptoms and laboratory results;

·       critique available therapies based on mechanism of action and determine which may be appropriate in TA-TMA vs. other TMA syndromes;

·       formulate an appropriate work-up to rule out other TMA syndromes and common post-transplant complications; and

·       distinguish clinical scenarios of TA-TMA patients that may benefit from therapeutic plasma exchange (TPE).