Case Reports Hematopathology 2022 Exercise 6: Clonal Hematopoiesis of Indeterminate Potential

Authors

Naomi Akagi, MD

Anne Deucher, MD, PhD

Yi Xie, MD, PhD

Department of Pathology and Laboratory Medicine

University of California San Francisco

San Francisco, California

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·       explain how clinical and laboratory findings fulfill criteria for clonal hematopoiesis of indeterminate potential (CHIP);

·       describe the most common genetic mutations identified in patients with CHIP;

·       apply the diagnostic criteria to correctly identify precursor entities such as idiopathic cytopenia of undetermined significance, idiopathic dysplasia of unknown significance, CHIP, and clonal cytopenia of undetermined significance; and

·       discuss the clinical implications of recognizing these precursor conditions.