Case Reports Renal Pathology 2022 Exercise 3: Anti–Glomerular Basement Antibody Disease

Authors

Zhengchun Lu, MD, PhD

Nicole Andeen, MD

Department of Pathology

Oregon Health & Science University

Portland, Oregon

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants, Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·         recognize the clinical and laboratory presentation of anti–glomerular basement antibody (anti-GBM) disease in different age groups;

·         describe the characteristic features of anti-GBM disease on a kidney biopsy, variant forms, and differential diagnosis;

·         explain the proposed pathogenic mechanisms of anti-GBM disease;

·         describe the features and potential significance of other autoantibodies commonly found in patients with anti-GBM disease, at and preceding diagnosis; and

·         discuss treatment and outcomes for anti-GBM disease.