Author
Catherine L. Omosule, PhD
Washington University in St Louis School of Medicine
St Louis, Missouri
Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants, Laboratory Directors and Educators
Upon completion of this activity, you will be able to:
· describe the clinical and biochemical features associated with monocarboxylate transport 8 deficiency, which causes Allan-Herndon Dudley syndrome (AHDS);
· describe the biology of 3,5,3’-triiodotyroacetic acid (TRIAC) and its role in the management of AHDS;
· describe laboratory tests used to assess thyroid function in the clinical laboratory; and
· assess whether equilibrium dialysis-liquid chromatography-tandem mass spectrometry is preferred over standard immunoassays for quantifying both free and total triiodothyronine in patients undergoing TRIAC therapy.