Case Reports Clinical Chemistry 2023 Exercise 6: 3,5,3’ -Triiodothyroacetic Acid Interference with Thyroid Hormone Assays

Author

Catherine L. Omosule, PhD

Washington University in St Louis School of Medicine

St Louis, Missouri

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·         describe the clinical and biochemical features associated with monocarboxylate transport 8 deficiency, which causes Allan-Herndon Dudley syndrome (AHDS);

·         describe the biology of 3,5,3’-triiodotyroacetic acid (TRIAC) and its role in the management of AHDS;

·         describe laboratory tests used to assess thyroid function in the clinical laboratory; and

·         assess whether equilibrium dialysis-liquid chromatography-tandem mass spectrometry is preferred over standard immunoassays for quantifying both free and total triiodothyronine in patients undergoing TRIAC therapy.