Case Reports Surgical Pathology 2023 Exercise 1: TFE3-Rearranged, TFEB-Rearranged, and TFEB-Amplified Renal Cell Carcinomas

Authors

Justin Chang, MD, MS

Selavaraj Mutusamy, MBBS, PhD

Steven Christopher Smith, MD, PhD

Virginia Commonwealth University, School of Medicine

Richmond, Virginia

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants, Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·       identify renal cell carcinomas (RCCs) showing features meriting diagnostic workup for TFE3-rearranged or TFEB-altered RCC subtypes; 

·       explain the clinicopathologic, histologic, and molecular features of TFE3-rearranged RCCs;

·       explain the clinicopathologic, histologic, and molecular features of TFEB-altered RCCs, including both TFEB-rearranged and TFEB-amplified RCCs; and

·       employ ancillary testing to resolve differential diagnoses of tumors in this growing spectrum of RCC.