Case Reports Surgical Pathology 2023 Exercise 5: Porocarcinoma: A Rare Entity with a Focus on Immunohistochemical and Molecular Developments

Author

Jennifer Crimmins, MD

Department of Pathology

Duke University Medical Center

Durham, North Carolina

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants, Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·         identify the histopathologic characteristics of poroma and its malignant counterpart, porocarcinoma;

·         differentiate poroma and porocarcinoma from other benign and malignant cutaneous neoplasms;

·         discuss the importance of differentiating porocarcinoma from common histologic mimic, cutaneous squamous cell carcinoma;

·         discuss the recent advances in molecular genetic alterations in poroma and porocarcinoma;

·         summarize the benefit and limitations of available immunohistochemistry in differentiating porocarcinoma from histologic mimics, particularly squamous cell carcinoma.