Author
Satoru Kudose, MD
Columbia University Irving Medical Center
New York, New York
Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants, Laboratory Directors and Educators
Upon completion of this activity, you will be able to:
· describe the basic structure of immunoglobulins;
· explain why immunoglobulins are named as they are;
· describe the major structural and functional differences between IgG subclasses;
· outline how IgG subclass staining is generally interpreted;
· explain why heavy and light chain restricted staining in kidney biopsies do not prove monoclonality; and
· distinguish several different strategies to detect IgG subclass in tissue by immunofluorescence.