Case Reports Renal Pathology 2024 Exercise 2: Thin Glomerular Basement Membrane Lesion/Nephropathy and Collagen IV Variants

Authors

Jonathan Bettencourt, DO

Nicole Andeen, MD

Department of Pathology & Laboratory Medicine

Oregon Health & Science University

Portland, Oregon

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants, Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·         recognize the clinical presentation of Alport syndrome and thin basement membrane lesion/nephropathy;

·         describe the pathologic features of Alport syndrome and thin basement membrane lesion/nephropathy on kidney biopsy;

·         discuss the components of the glomerular basement membrane and its development;

·         describe associations of COL4A3-COL4A5 in other kidney diseases; and

·         discuss indications for COL4A3-COL4A5 genetic testing in patients with kidney disease.