Case Reports Renal Pathology 2023 Exercise 2: Non-PLA2R Membranous Antigens: An Update

Author

Nicole Andeen, MD

Department of Pathology & Laboratory Medicine

Oregon Health & Science University

Portland, Oregon

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants, Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·         recognize the clinical and pathologic features of membranous nephropathy (MN) associated with the phospholipase A₂ receptor (PLA2R) antigen;

·         describe the clinical and pathologic features of MN associated with neural epidermal growth factor-like 1 (NELL1) antigen;

·         discuss the current knowledge on the 3 known antigens in membranous lupus nephritis; and

·         discuss the antigens identified in specific clinical groups: patients with previous hematopoietic stem cell transplant, patients with underlying malignancies, and pediatric patients.