Case Reports Hematopathology 2023 Exercise 4: Mature Plasmacytoid Dendritic Cell Proliferation Associated with Myeloid Neoplasm: A Novel Entity in the 5th Edition of The World Health Organization Classification of Haematolymphoid Tumours

Authors

Azal Al Ani, MD

Yanhua Wang, MD, PhD

Yang Shi, MD

Department of Pathology

Montefiore Medical Center

Albert Einstein College of Medicine

Bronx, New York

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·         describe the histopathologic and immunophenotypic characteristics of mature plasmacytoid dendritic cell proliferation (MPDCP) associated with myeloid neoplasm;

·         discuss the prognosis and treatment options for MPDCP associated with myeloid neoplasm;

·         develop differential diagnoses for MPDCP with associated myeloid neoplasm and blastic PDC neoplasm;

·         discuss the newly proposed subtype of acute myeloid leukemia with PDC differentiation; and

·         identify the reactive PDC proliferation associated with reactive conditions such as Kikuchi histiocytic necrotizing lymphadenitis, Castleman disease, and systemic lupus erythematosus.