Case Reports Hematopathology 2023 Exercise 2: T-Cell Prolymphocytic Leukemia

Authors

Salima Mansoor Ali, MD

Patricia Tsang, MD, MBA

Department of Pathology and Laboratory Medicine

Medstar Washington Hospital Center

Washington, DC      

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·         explain the clinical presentation and prognosis of T-cell prolymphocytic leukemia (T-PLL);

·         recognize the microscopic features of T-PLL in the blood, bone marrow, and skin biopsy;

·         describe the characteristic phenotypic and genotypic profiles of T-PLL;

·         discuss the role of genetic tests, such as cytogenetics, fluorescence in situ hybridization, and molecular genetic tools, in the diagnostic evaluation of T-cell lymphoid neoplasms involving the bone marrow and blood; and

·         discuss the top differential diagnoses of mature T-PLL.