Case Reports Hematopathology 2023 Exercise 5: EBV-Positive Plasmacytoma vs Indolent Plasmablastic Lymphoma: A Diagnostic Dilemma

Authors

Brenda Mai, MD

Ingold Huang, MD

Anjanaa Vijayanarayanan, MD

Sonam Prakash, MD

Yi Xie, MD, PhD

Department of Pathology and Laboratory Medicine

University of California San Francisco

San Francisco, California

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·         describe the immunophenotype of normal versus neoplastic plasma cells;

·         describe the differential diagnosis of plasma cell lesions;

·         describe the clinical presentation that can be seen in plasmacytomas;

·         describe the histologic and immunophenotypic findings that can be seen in a plasmacytoma;

·         describe the histologic and immunophenotypic findings that can be seen in plasmablastic lymphoma; and

·         discuss the challenges in the diagnosis of an Epstein-Barr virus–positive plasmacytoma.