Case Reports Hematopathology 2023 Exercise 3: T-Cell/Histiocyte Rich Large B-Cell Lymphoma

Authors

Constantine Kanakis, MD, MSC

Kamran Mirza, MD, PhD

Department of Pathology and Laboratory Medicine

Loyola University Medical Center

Maywood, Illinois      

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·         recognize the general clinical presentation of diffuse large B-cell lymphoma (LBCL);

·         establish a working differential diagnosis of LBCLs following an initial laboratory investigation;

·         identify key morphologic findings in a case of LBCL;

·         describe the morphologic and phenotypic profile of malignant cells in T-cell/histiocyte–rich LBCL (THRLBCL);

·         order the correct ancillary studies in cases of suspected B-cell malignancy; and

·         formulate a plan to incorporate rare entities, such as THRLBCL, into routine workup of hematologic malignancy evaluation.