Case Reports Hematopathology 2024 Exercise 2: ALK-Negative Anaplastic Large Cell Lymphoma with DUSP22 Rearrangement

Authors

Mingfei Yan, MD, PhD

Mariko Yabe, MD, PhD

Department of Pathology and Laboratory Medicine

Memorial Sloan Kettering Cancer Center 

New York, New York

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·       explain the classifications of anaplastic large cell lymphomas (ALCLs);

·       summarize the clinicopathologic features of both systemic and localized ALCLs;

·       discuss the differential diagnosis for ALK-negative ALCL with DUSP22 rearrangement, especially in relation to other lymphomas that can also harbor DUSP22 rearrangement; and

·       select appropriate immunohistochemical and molecular genetic ancillary tests to accurately diagnose ALCLs.