LabQ Clinical 2025 Exercise 8: Hematology: T-cell Large Granular Lymphocytic Leukemia

Author(s)

Wei J Wang, MD

Jie Xu, MD PhD

MD Anderson Cancer Center

University of Texas

Houston, Texas

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·       describe the morphologic characteristics of T-cell large granular lymphocytic leukemia (T-LGLL) in peripheral blood and bone marrow aspiration smear;

·       understand the definition of T-LGLL and diagnostic criteria of T-LGLL;

·       know the immunophenotypic and genetic characteristics of T-LGLL; and

·       discuss the prognosis and treatment of T-LGLL.