LabQ Clinical 2025 Exercise 9: Hematology: T-Prolymphocytic Leukemia

Author(s)

Wei J Wang, MD

Jie Xu, MD PhD

MD Anderson Cancer Center

University of Texas

Houston, Texas

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·       describe the morphologic characteristics of T-prolymphocytic leukemia (T-PLL) cells in peripheral blood smear;

·       list the systemic symptoms and laboratory results associated with T-PLL;

·       know the immunophenotypic, cytogenetic, and molecular characteristics of T-PLL;

·       understand the diagnostic criteria of T-PLL; and

·       discuss the prognosis of T-PLL.