Case Reports Transfusion Medicine 2023 Exercise 5: Atypical Hemolytic Uremic Syndrome

Author

Aaron D. Schmookler, MD

Department of Pathology

University of Kentucky College of Medicine

Lexington, Kentucky

Adapted from Ipe T. Atypical hemolytic uremic syndrome. ASCP Case Rep Transfus Med. 2015;15(7).

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·         differentiate atypical hemolytic uremic syndrome (aHUS) from other thrombotic microangiopathies, such as thrombotic thrombocytopenic purpura and Shiga toxin–producing enterohemorrhagic Escherichia coli hemolytic uremic syndrome;

·         analyze clinical and laboratory presentations associated with aHUS;

·         describe the pathogenesis of aHUS;

·         choose appropriate laboratory tests for the diagnosis of aHUS; and

·         appraise the utility of plasma exchange and monoclonal antibody therapy for aHUS.