Case Reports Transfusion Medicine 2023 Exercise 6: Nothing But a “G” Thing: Prophylaxis of RhD Alloimmunization in Setting of Anti-G

Authors

Noah Mehr, MD

Timothy Carll, MD

Department of Pathology

The University of Chicago Medicine

Chicago, Illinois

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·         explain the pathophysiology underlying hemolytic disease of the fetus and newborn;

·         explain the utility of RhD immune globulin in the prevention of maternal alloimmunization to RhD;

·         discuss the significance of distinguishing anti-G patterns of reactivity from anti-D and anti-C;

·         summarize the process of adsorption studies in distinguishing anti-G from anti-D and anti-C;

·         discuss the most common methods of quantifying fetomaternal hemorrhage (Kleihauer-Betke, fetal hemoglobin flow cytometry), and their relative strengths and weaknesses; and

·         calculate appropriate RhIg dosage in the setting of fetomaternal hemorrhage.