Author(s)
Arevik Ghazaryan, PhD
Clinical Immunology Fellow
Abdulrahman Saadalla, MB, BCh
Medical Director, Immunology
University of Utah School of Medicine
ARUP Laboratories
Salt Lake City, Utah
Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants, Laboratory Directors and Educators
Upon completion of this activity, you will be able to:
· discuss the clinical manifestations of antiphospholipid syndrome (APS) and the laboratory criteria required for diagnosis;
· recognize the importance of repeat testing to confirm the persistence of antiphospholipid antibodies;
· describe the common assays used for lupus anticoagulant (LAC) detection; and
· discuss the weighted scores approach used in the 2023 ACR/EULAR classification criteria for anti-cardiolipin and anti-beta-2 glycoprotein-1 antibodies based on titers and isotypes.