ANA / ENA Autoimmune Testing

This is an online commentary on Immunology offering 1.0 continuing education (CME/CMLE) credit that can be used to fulfill CC Part II and CMP requirements.

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On completion of this exercise, the participant should be able to:

explain the role of antinuclear antibodies (ANAs), anti–double-stranded DNA (anti-dsDNA), and extractable nuclear antigen antibodies (ENAs) testing in the diagnosis of autoimmune disease;
describe laboratory methods used...

On completion of this exercise, the participant should be able to:

explain the role of antinuclear antibodies (ANAs), anti–double-stranded DNA (anti-dsDNA), and extractable nuclear antigen antibodies (ENAs) testing in the diagnosis of autoimmune disease;
describe laboratory methods used to detect ANAs, dsDNA, and ENAs;
discuss common patterns detected with the indirect immunofluorescence assay ANA test;
discuss the challenges of autoantibody testing;
apply the Choosing Wisely guidelines to determine when it is appropriate to order autoantibody testing.

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