LabQ Clinical Exercise 4: Clinical Immunology: THERAPEUTIC DRUG MONITORING OF MONOCLONAL ANTIBODY THERAPIES IN INFLAMMATORY BOWEL DISEASE

PAOLA A. RAMOS, PHD

DEPARTMENT OF LABORATORY MEDICINE AND PATHOLOGY

MAYO CLINIC

Rochester, Minnesota

MARIA ALICE WILLRICH, PHD, DABCC, FAACC

DEPARTMENT OF LABORATORY MEDICINE AND PATHOLOGY

MAYO CLINIC

Rochester, Minnesota

Primary Audience: Phlebotomists, Laboratory Technologists, Laboratory Directors

Secondary Audience: Pathologists, Clinical Scientists (Includes all sub-specialty areas), Students, Pathologist Assistants, Residents, and Students

Upon completion of this activity, you will be able to:

·         identify the need for therapeutic monitoring of monoclonal antibody therapies;

·         explain the concept of immunogenicity and appearance of antidrug antibodies;

·         evaluate laboratory findings suggestive of loss of response to therapy; 

·         describe different scenarios when therapeutic drug monitoring is utilized; and

·         develop an interpretation plan for test orders of monoclonal antibody therapies.