Case Reports Renal Pathology 2025 Exercise 1: Autosomal Dominant Polycystic Kidney Disease

Authors

Brenna Stevens, MD

Nicole Andeen, MD

Department of Pathology & Laboratory Medicine

Oregon Health & Science University

Portland, Oregon

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·       recognize the clinical presentation and radiographic features of autosomal dominant polycystic kidney disease (ADPKD);

·       describe the gross and microscopic features of ADPKD on nephrectomy;

·       discuss pathophysiology of cyst formation and disease progression in ADPKD;

·       discuss the genes and proteins implicated in ADPKD, and challenges in genetic test interpretation; and

·       describe the differential diagnosis of ADPKD.