Case Reports Hematopathology 2025 Exercise 4: Cyclin D1-Negative Mantle Cell Lymphoma

Authors

Yi Xie, MD, PhD

Associate Clinical Professor

Department of Laboratory Medicine

University of California San Francisco

San Francisco, California

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

• describe clinical, histologic, immunophenotypic and genetic features of mantle cell lymphoma;
• describe the differential diagnoses for mantle cell lymphoma;
• recognize the challenges in the diagnosis of cyclin D1-negative mantle cell lymphoma; and
• select appropriate diagnostic tests to differentiate cyclin D1-negative mantle cell lymphoma from other entities in its differential diagnosis.