Case Reports Surgical Pathology 2025 Exercise 1: Metastatic Appendiceal Adenocarcinoma to the Uterus in a Patient with Endometrioid Adenocarcinoma

Authors

Eric J Magnetta, MD

Dina H Kandil, MD

Department of Pathology

UMass Chan Medical School

Worcester, Massachusetts

Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants,  Laboratory Directors and Educators

Upon completion of this activity, you will be able to:

·       recognize the histologic features of metastatic adenocarcinoma to the uterus;

·       recognize the differential diagnosis of endometrial adenocarcinoma with metastasis versus synchronous tumors;

·       identify the optimal immunoprofile to differentiate endometrial adenocarcinoma from metastatic mucinous adenocarcinoma of gastrointestinal origin; and

·       understand the importance of effective communication between the pathologist and the gynecologic surgeon during surgery for appropriate staging and management of gynecologic cancer patients.