Authors
May Ye Mon, MD
Amber R Prete, MD
Department of Pathology
Virginia Commonwealth University
Steven Christopher Smith, MD, PhD
Department of Surgery
Virginia Commonwealth University
Richmond, Virginia
Primary Audience: Pathologists and Clinical Scientists
Secondary Audience: Residents, Laboratory Technologist/Scientist (Includes all sub-specialty areas), Students, Pathologist Assistants, Laboratory Directors and Educators
Upon completion of this activity, you will be able to:
· describe the genetic and molecular pathogenesis of DICER1 syndrome;
· discuss several common neoplastic manifestations of DICER1 syndrome;
· recognize the clinical and histologic features of pediatric cystic nephroma and anaplastic sarcoma of the kidney; and
recommend immunohistochemical and molecular diagnostic testing to differentiate pediatric cystic nephroma from adult cystic nephroma and cystic partially differentiated nephroblastoma.